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The pathophysiological mechanisms are believed to be interconnected between immune, inflammatory, neurotransmitter, genetic, and oxidative pathways (Pun et al., 2009

The correlation between male and female annualized rates of decline in the same county was moderate at 0.55

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So, for people with type 1 diabetes who smoke, not only does the body not produce enough insulin due to the disease, but insulin resistance caused by smoking makes it harder for the body to respond to insulin therapy

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